翻訳と辞書 Words near each other ・ Capperia ningoris ・ Capperia polonica ・ Capperia raptor ・ Capperia salanga ・ Capperia taurica ・ Capperia trichodactyla ・ Capperia washbourni ・ Capperia zelleri ・ Capperonnier ・ Capper–Ketcham Act ・ Capper–Volstead Act ・ Cappetta ・ Cappie Pondexter ・ Cappielow ・ Capping ・ Capping enzyme ・ Capping inversion ・ Capping protein (actin filament) muscle Z-line, alpha 1 ・ Capping Show ・ Capping stunt ・ Capping week ・ Cappon magro ・ Capponi Chapel ・ Cappont ・ Cappoquin ・ Cappoquin House ・ Capppancur ・ Cappriccieo Scates ・ CAPPS ・ Capps Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Capping enzyme ： ウィキペディア英語版 Capping enzyme A capping enzyme (CE) is an enzyme that catalyzes the attachment of the 5' cap to messenger RNA molecules that are in the process of being synthesized in the cell nucleus during the first stages of gene expression. The addition of the cap occurs co-transcriptionally, after the growing RNA molecule contains as little as 25 nucleotides. The enzymatic reaction is catalyzed specifically by the phosphorylated carboxyl-terminal domain (CTD) of RNA polymerase II. The 5' cap is therefore specific to RNAs synthesized by this polymerase rather than those synthesized by RNA polymerase I or RNA polymerase III. Pre-mRNA undergoes a series of modifications - 5' capping, splicing and 3' polyadenylation before becoming mature mRNA that exits the nucleus to be translated into functional proteins and capping of the 5' end is the first of these modifications. Three enzymes, RNA triphosphatase, guanylyltransferase (or CE), and methyltransferase are involved in the addition of the methylated 5' cap to the mRNA. ==Formation of the cap== Capping is a three-step process that utilizes the enzymes RNA triphosphatase, guanylyltransferase, and methyltransferase. Through a series of three steps, the cap is added to the first nucleotide's 5' hydroxyl group of the growing mRNA strand while transcription is still occurring.〔 First, RNA 5' triphosphatase hydrolyzes the 5' triphosphate group to make diphospate-RNA. Then, the addition of GMP by guanylyltransferase produces the guanosine cap. Last, RNA methyltransferase transfers a methyl group to the guanosine cap to yield 7-methylguanosine cap that is attached to the 5' end of the transcript.〔〔〔 These three enzymes, collectively called the capping enzymes, are only able to catalyze their respective reactions when attached to RNA polymerase II, an enzyme necessary for the transcription of DNA into pre-mRNA. When this complex of RNA polymerase II and the capping enzymes is achieved, the capping enzymes are able to add the cap to the mRNA while it is produced by RNA polymerase II.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Capping enzyme」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.